I recently had problem with Unlocker because Avast antivirus keeps on deleting the unlocker executable and treating it as W32:Malware-gen. I did a full scan and didn't find any virus on my machine. I still don't know if this is a false positive or a legit detection. Maybe on my next avast virus definition update i'll see some changes.
I'm sure that some of us has Unlocker installed and is actively using this whenever there's a write protect/file in use error. I found other tools that can be use as an alternative if in case your antivirus starts to hate your installed Unlocker.
File & Folder Unlocker
LockHunter
FileASSASSIN
